PEX6 and Usher syndrome: For Family 5, of Yemenite Jewish Israeli origin and not known to be consanguineous, a known homozygous variant, c.[1715C>T][1715C>T], p.[(T572I)][(T572I)], in PEX6 was identified.21, 23 This variant was previously reported in an individual of mixed Yemenite and Ashkenazi Jewish origin, initially diagnosed with Usher syndrome and subsequently diagnosed with ZS.23