When the dose of CD44-IR700 was increased to 300 μg for a one-time injection, the irradiated MDA-MB-231 tumor shrank dramatically, and only a minimal amount of tumor tissue remained at the end of treatment, while the unirradiated tumor on the right was not affected, and showed a tumor growth pattern similar to the control agent-treated tumors (Fig. 5a,c). This evidence concerns the gene CD44 and neoplasm.