However, only the CMS1 tumours remained significantly associated with worse survival in the multivariable model upon adding APC and BRAF plus AKP and APC two-mutation (HR=2.39, χ2P=0.012, Model 4) or plus APC(2)KP (HR=2.55, χ2P=0.007, Model 5). The gene discussed is BRAF; the disease is neoplasm.