Compared with Class 1 (reference) tumours, while APCwt (Class 0) tumours still carried substantially worse survival (hazard ratio (HR)=1.94, χ2P=0.0023), the AKP triply mutated tumours with two APC mutations (Class 4) had the worst survival (HR=2.48, χ2P=0.0011). Here, APC is linked to neoplasm.