Notably, adding metastasis led to a significant HR for two-hit APC mutation tumours (HR=1.58, χ2P=0.027, Model 3) but decreased the HR of AKP from 1.79 (χ2P=0.005, Model 2) to 1.43 (χ2P=0.090, Model 3) probably because of the very strong correlation of AKP with distant metastasis. Here, APC is linked to neoplasm.