TP53 and neoplasm: Since both AKP triply mutated and other APC-mutated tumours had either one or two APC mutations, we further re-grouped these MSS tumours into five classes: Class 0 (n=111): ‘APCwt'; Class 1 (n=135): ‘APC(1), APC(1)/KRAS, APC(1)/TP53'; Class 2 (n=76): ‘APC(2), APC(2)/KRAS, APC(2)/TP53'; Class 3 (n=45): ‘APC(1)/KRAS/TP53' (APC(1)KP for short); and Class 4 (n=40): ‘APC(2)/KRAS/TP53' (APC(2)KP for short).