An APC mutation was found to be a moderate good risk factor, with an HR of 0.65 (χ2P=0.021), while tumours with KRAS and TP53 mutations were in moderate poor risk, with HRs in the 1.4–1.6 range; a BRAF mutation, although rare (only 18/407 tumours, 4.4%), had a dramatic HR of 2.63 (in agreement with several recent reports indicating BRAF(V600E) as a strong negative prognostic marker of CRC30, 31, 32, 33, 34, 35), while the HR was 1.05 per year over the age of 70. The gene discussed is BRAF; the disease is neoplasm.