However, the AKP tumours with one APC mutation (Class 3) and other APC two-mutation (Class 2) tumours were no longer significantly associated with worse survival (HR=1.48, χ2P=0.17 and HR=1.11, χ2P=0.67, respectively) in this refined model, suggesting that either AKP or two APC mutations alone were separately insufficient for prediction of worse survival. Here, APC is linked to neoplasm.