Furthermore, addition of APC(2)KP (Class 4) that replaced AKP and two-hit APC mutations showed a substantially significant HR (HR=2.10, χ2P=0.003; Table 5; Model 4), supporting Class 4 tumours as a worst-risk class as shown earlier in the Kaplan-Meier (KM) survival analysis (Fig. 3d). The gene discussed is APC; the disease is neoplasm.