An APC mutation was found to be a moderate good risk factor, with an HR of 0.65 (χ2P=0.021), while tumours with KRAS and TP53 mutations were in moderate poor risk, with HRs in the 1.4–1.6 range; a BRAF mutation, although rare (only 18/407 tumours, 4.4%), had a dramatic HR of 2.63 (in agreement with several recent reports indicating BRAF(V600E) as a strong negative prognostic marker of CRC30, 31, 32, 33, 34, 35), while the HR was 1.05 per year over the age of 70. This evidence concerns the gene APC and neoplasm.