The authors showed that NAFLD leads to significant changes in the plasma BA profile, which appears to be based on an activation of the CYP7B1 dependent alternative BA synthesis pathway, putatively induced by expression changes of BA synthesizing enzymes, such as CYP8B1, CYP7B1 and CYP27A1 [19]. The gene discussed is CYP8B1; the disease is metabolic dysfunction-associated steatotic liver disease.