We detected important genes responsible for phase I (CYP1A1, CYP1A2, CYP2B6, besides CYP2C19 [8]), phase II (GSTP1, SULT1A1, SULT1A4, UGT2B7) and phase III (SLC47A1) to show NAFLD dependent methylation changes that are associated with inverse transcriptional changes. The gene discussed is SULT1A4; the disease is metabolic dysfunction-associated steatotic liver disease.