Consistent with these histological observations, liver fibrosis-related genes such as Col1a1, TGF-beta1 and Acta2, and inflammatory genes such as MCP-1, KC, MIP-1α, CD11c and F4/80, were highly induced Creb3l3−/− mice (Fig. 4D,E). Here, CALCA is linked to Hepatic fibrosis.