As Fig. 1 shown, concentrations of TNF-α {P < 0.01 (Day 3-5), P < 0.01 (Day 6-7), P < 0.01 (Day 8-10), Fig. 1a}, IL-1α {P = 0.003 (Day 3–5), P < 0.01 (Day 6–7), P < 0.01 (Day 8–10), Fig. 1b} and IFN-γ {P = 0.047 (Day 3–5), P = 0.074 (Day 6–7), P = 0.161(Day 8–10), Fig. 1c} were significantly elevated in dengue patients compared to healthy controls at early stage of illness. This evidence concerns the gene TNF and dengue disease.