It seems that AG genotype of UCP2 is an important genetic predisposing factor of metabolic disease including obesity and T2DM [24, 45, 46]; in parallel of these observations, our study is the first study reported the gene-nutrient interactions between −866 A/G of UCP2 gene polymorphism and NAFLD. The gene discussed is UCP2; the disease is obesity due to melanocortin 4 receptor deficiency.