Although Lp-PLA2 produces the pro-inflammatory mediators lysophosphatidylcholine and oxidized free fatty acids through hydrolysis of oxidized phospholipids on LDL, it also has anti-inflammatory activity through degradation of platelet-activating factor,3 and its biological role in the initiation and progression of atherosclerosis is uncertain.4 Here, PLA2G7 is linked to atherosclerosis.