SMAD4 and Inherited cancer-predisposing syndrome: These genes included MLH1, MSH2, MSH6, PMS2, CDH1, APC, MUTYH, STK11, SMAD4, PTEN, BMPR1A, BRCA1/2, and EPCAM which were well studied in various hereditary cancer syndromes.79.6% cases (43/54) carried at least one pathogenic mutation in 13 genes (Table 3), and pathogenic mutation in EPCAM was not detected.