Because according to RNA-seq analysis IL-10 mRNA was upregulated by YopM already after 1.5 h and also after 6 h of infection (orange cluster) and IL-10 protein levels were previously found to be elevated by YopM in the serum of infected mice [8, 29], we sought to confirm and further analyze the YopM effect on IL-10 expression. The gene discussed is IL10; the disease is infection.