The low incidence of MET gene amplification, mutation and/or overexpression in primary prostate tumor samples analyzed by TCGA suggests that Met protein quantitation and activation status may have value in follow-up to genomic and/or transcriptomic-based screens that show evidence of these oncogenically relevant features, to more directly guide therapeutic strategy and for pharmacodynamic evaluation of Met-targeted therapeutics. The gene discussed is MET; the disease is prostate neoplasm.