Of these, ZIP1 is believed to be ubiquitously expressed in the body.62ZIP1 is highly expressed in the hippocampus and in murine studies, and knocking out ZIP1 attenuated seizure-induced neuronal death.63ZIP1 expression can be upregulated by interleukin-6 and at least in the prostate also is increased by testosterone.62 Dietary zinc deficiency mainly affects the subcellular location of ZIP1 leading to an increased presence in the plasma membrane,64 highlighting the need for further studies of the protein levels of ZIP1 in the aging brain. This evidence concerns the gene IL6 and Zinc deficiency.