SLC30A3 and Alzheimer disease: An age-related ZNT3 downregulation has been reported in an older human population (n=24)—age 49–91 years—as well as in aging rodents.30 The ZNT3 protein is responsible for the accumulation of zinc in synaptic vesicles and could be involved in memory and learning.28 A reduction in ZNT3 expression has been found in the brains of AD patients.