The main risk factors of sporadic AD are advanced age ApoE genotype and diabetes.4, 5 Moreover, several studies find that obesity per se increases the risk of developing dementia.6, 7, 8, 9, 10, 11 There is a correlation between obesity in early and midlife and the subsequent development of AD in later years. This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.