TERT and Anxiety: We also measured anxiety-related behavior by performing an EMT and a light–dark test.25, 26Tert−/− mice showed decreased entry time in the open arm in the EMT (P=0.0177, t-test; WT, n=19; Tert−/− mice, n=17) and in the light box in the light-dark test (P=0.0003, t-test; WT, n=18; Tert−/− mice, n=16), indicating that Tert−/− mice displayed elevated anxiety compared with WT mice (Figure 1c).