SDC1 and preeclampsia: As shown in Fig 2, soluble Sdc1 concentrations were significantly lower, weeks before clinical development of preeclampsia [median ng/mL 174 (range 48–353)], but not gestational hypertension [242 (111–1187)], compared to controls [272 (78–1463)] (P<0.05, Kruskal-Wallis, post hoc Dunn’s).