Comparing the preeclampsia and uncomplicated pregnancy placentas exposed to labor, the intensity score for Sdc1 on syncytiotrophoblast was significantly lower in preeclampsia with labor (n = 16) [2.25 (2.0–3.0)] vs. controls with labor (n = 13) [(3.0 (2.5–4.0)] (P<0.03). Here, SDC1 is linked to preeclampsia.