In a murine tumor model of lymphoma they demonstrated superior efficiency using a CAR T cell formulation consisting of CD4 T cells derived from the naïve CD4 T cell pool with CD8 T cells derived from central memory CD8 T cells at a 1 : 1 ratio, compared to unselected batch T cells and CD8 or CD4 cells alone [70]. This evidence concerns the gene CD8A and neoplasm.