ERBB2 and neoplasm: Combination of ATC with checkpoint inhibitor blockade using antagonistic antibodies against the negative regulators CTLA-4 and PD-1/PD1-L has also been suggested, and it has been demonstrated that the specific blockade of the PD-1 immunosuppressive pathway significantly enhanced the function of HER2 redirected CAR expressing T cells leading to enhanced tumor eradication in immune competent HER2 transgenic mice [91].