Additionally, E2 reduces Aβ-induced cell death and Aβ-induced elevation of Ca2+ in hippocampal neurons [34], and it prevents the hyperphosphorylation of tau, another cause of AD (for review [35]), and has recently been shown to rescue bioenergetic deficits in mitochondria induced by Aβ and hyperphosphorylated tau [36]. This evidence concerns the gene MAPT and Alzheimer disease.