To examine how mitochondrial epigenetics interacts with A1c, FG, and insulin resistance, we collected additional blood samples from a subset (40 out of the 87, including 8 lean/healthy, and 32 obese) of participants and analyzed DNA methylation in mitochondrial ND6 and D-loop, the regions critical for mitochondrial function and DNA replication [18, 32]. The gene discussed is MT-ND6; the disease is Insulin resistance.