Of note, although Lyn and Syk phosphorylation were detected in 6-month-old transgenic B cells, activation of PI3K-AKT or NF-κB signalling were detected in 18-month-old clonal lymphoma cells but not in younger mice, demonstrating them to be late events during lymphoma development (Supplementary Fig. 5b,c). The gene discussed is LYN; the disease is lymphoma.