Remarkably, increased expression of multiple cell surface proteins implicated in homing and cell motility was detected in the tumour cells, including integrins such as LFA-1 (CD11a), VLA-4 (CD49d) and MAC-1 (CD11b), and adhesion molecules such as MadCAM-1, ICAM-1 (CD54) and L-selectin (CD62L). This evidence concerns the gene ITGAL and neoplasm.