A progressive development of small-to-medium sized clusters composed of LFA-1- and ICAM-1-expressing cells intermingled with IgM-producing cells was documented in 12-month-old tumours, reflecting that the cluster formation was facilitated by adhesion molecules and integrins that favoured adhesion of B cell among themselves and with surrounding environmental cells, promoting the development of large non-clonal tumour masses. Here, ICAM1 is linked to neoplasm.