In 2005, the presence of aCL was detected in 33 of 63 diseased dogs by setting a cut-off value based on the sera of 134 healthy dogs, and four APS-like diseased dogs, including one dog with recurrent abortion and severe thrombocytopenia, were found to have high levels of aCL [13]. This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.