Various forms of cleaved tau initiate tau aggregation, suggesting that this process may be critical for tauopathy pathogenesis (Wischik et al., 1988; Chung et al., 2001; Arai et al., 2004; Zilka et al., 2006; Zhang et al., 2014; Melis et al., 2015). The gene discussed is MAPT; the disease is tauopathy.