More so, a recent report has indicated that the neuroligin-3 mutation related to autism causes a disruption in tonic eCB signaling within the hippocampus (Földy et al., 2013), resulting in an increase in GABA release and a shift in the E/I balance of the hippocampus that is the exact opposite of what was produced by PAK1 disruption. Here, PAK1 is linked to autism.