Quite interestingly, many of these same animal models of neurodevelopmental disorders also exhibit pronounced alterations in eCB signaling (Földy et al., 2013; Jung et al., 2012), and several reports have now suggested that, like PAK1, targeting eCB signaling may provide benefit in these conditions (Busquets-Garcia et al., 2013; Qin et al., 2015). Here, PAK1 is linked to neurodevelopmental disorder.