The relative amounts of neuronal and glial accumulation and the neuroanatomical distribution of tau define a range of neurodegenerative tauopathies, including tangle predominant dementia [4, 5], argyrophilic grain disease (AGD) [6], Pick disease (PiD) [7], progressive supranuclear palsy (PSP) [8] and corticobasal degeneration (CBD) [9]. This evidence concerns the gene MAPT and argyrophilic grain disease.