Third, TDP-43 associated AV-1451 binding is demonstrated as a sporadic finding (similar to the findings of Sander, et al,[38]) and additional patient examples are provided to demonstrate potential tauopathies underlying clinical phenotypes of FTD (Fig. 4) and are therefore additionally possible explanations for AV-1451 positive scans in FTD patients. The gene discussed is TARDBP; the disease is tauopathy.