THOP1 and early-onset autosomal dominant Alzheimer disease: When associated with canonical pathways, proteins related to ASS were divided into classes consisting of LXR/RXR Activation; FXR/RXR Activation; Acute Phase Response Signaling; Neuroprotective Role of THOP1 in Alzheimer’s Disease; the Intrinsic Prothrombin Activation Pathway and Coagulation System; Nitric Oxide and eNOS signaling (Fig. 1).