Several outlier genes whose knockdown confers striking vulnerability are tumor suppressors including APC [36], PHLPP1 [37] and SPEN [38], while a number of other candidates have been reported to harbor anti-oncogenic activities such as the pro-apoptotic gene MTCH2 [39] and the anti-metastatic RNA chaperone RBM47 [40]. The gene discussed is SPEN; the disease is neoplasm.