The presence of additional tumor suppressors like ARID1B and APC among outlier genes suggests that these are unlikely to be isolated cases and more may have context-dependent dual properties, presenting a challenge to the simple binary classification of cancer genes as either oncogenes or tumor suppressors, and bringing up the possibility of expanding the druggable genome to include tumor suppressors when coupled with an appropriate precision medicine strategy. The gene discussed is ARID1B; the disease is neoplasm.