For another lethal chondrodysplasia phenotype (OMIA 001926-9913) reported in Holstein cattle in 2004 [4] it was later demonstrated that the sire (Igale Masc) of affected calves was mosaic for a dominant acting collagen type II (COL2A1) missense mutation (pG600D) disrupting the Gly-X-Y structural motif essential for the assembly of the collagen triple-helix [5]. The gene discussed is COL2A1; the disease is chondrodysplasia.