However, the expression, clinical significance and biological function of HDAC4 in EC remain to be elucidated because HDAC4 only has been reported to be higher in 36 ESCC samples compared with the paired normal esophageal epithelial tissues [24] and there are no more findings on HDAC4 in ESCC. The gene discussed is HDAC4; the disease is esophageal squamous cell carcinoma.