Although it might be argued that, because mitophagy-deficient iPSC colonies tended to rapidly differentiate in vitro and exhibited a significantly reduced teratoma-initiating capacity, the percentage of fully reprogrammed cells might be significantly lower within PINK1−/−-iPSC colonies, these findings are also consistent with a more rapid differentiation of mitophagy-deficient iPSCs in vivo. Here, PINK1 is linked to teratoma.