APOE and aortic atherosclerosis: It must be noted that this epigenetic mechanism was also implicated in the downregulation of hepatic ABCA1 in apoE−/− mice with EZH2 overexpression, which accordingly impaired the lipidation of hepatic apoA-I and the recycling apoA-I at the hepatocyte surface and accelerated aortic atherosclerosis development [35].