MUC16 and neoplasm: Meanwhile, a series of tumor-associated, glycan-based antigens have already been isolated and validated to preferentially predict the presence of tumors in patients, and some have found clinical application as tumor markers, including carcinoembryonic antigen (CEA) [3,4], carbohydrate antigen 19–9 (CA 19–9) [5,6], α-fetoprotein (AFP) [7,8], cancer antigen 125 (CA125) [9,10], sialyl Lewis X-i (SLX-i) [11,12] and sialyl-Tn (STN) [13,14] antigens.