KRAS and colorectal cancer: Similarly, in colorectal cancer cell lines, RASSF1A epigenetic silencing varied with DLD-1 (Dukes’ type C colorectal adenocarcinoma with chromosomal and microsatellite instability and harboring mutations in K-Ras, p53 and PI3KC (P-I3-kinase), while wild-type for BRaf and PTEN [31]) and CaCO-2 having somewhat similar variation in individual CpG methylation.