RASSF1 and colonic neoplasm: In contrast, most of the cells from lung, cervical, colorectal, rectal, bladder cancers and glioblastoma tumors have RASSF1A methylation to >50% [3], and SssI methyltransferase can methylate colon cancer cells to >90% [22] to suggest robust DNA methylation susceptibility mechanisms within the 32 CpG sites on the RASSF1A promoter.