We also found that depletion of OLFM4 induced a more elongated and spindled morphologic change in gastric cancer cells, which was supported by our and other's observations that OLFM4 was correlated with gastric cancer differentiation.13 In addition, the underlying mechanism how OLFM4 modulates the differentiation of cancer cells may need further investigation. This evidence concerns the gene OLFM4 and gastric cancer.