(1) FABP4 is expressed in cardiomyocytes and can be up-regulated by PPARγ activation; (2) Cardiomyocyte-specific FABP4 mice developed aggravated cardiac hypertrophy under pressure overload; (3) FABP4 over-expression in cardiomyocyte activates ERK phosphorylation, and ERK inhibitor can abolish FABP4 induced cardiomyocytes hypertrophy effect. The gene discussed is PPARG; the disease is cardiac hypertrophy.