RHD and rheumatic heart disease: The index group consisted of 61 RHD positive children (30 with definite RHD and 31 with borderline RHD) and 67 RHD negative children (Table 1), generating a complete list of 320 (5.3/child) and 347 (5.2/child) first-degree family members of RHD positive and RHD negative index subjects, respectively, p = 0.22.