Frequency of structural alteration of DDIT4 found at cbioportal.org, indicate that 0 to 5.1% of primary tumors where DDIT4 was related with the prognostic had mutations, however in breast tumors xenografts, gene amplification occurs in 17.4% elucidating an key role in tumor aggressiveness. This evidence concerns the gene DDIT4 and breast neoplasm.