She was diagnosed with type 3 Alzheimer's disease [13, 14], and laboratory data supported this diagnosis with characteristic HLA-DR/DQ and abnormal C4a and TGF-β1, as well as anti-thyroglobulin antibodies and anti-thyroid peroxidase antibodies, although MARCoNS culture was negative. The gene discussed is TGFB1; the disease is early-onset autosomal dominant Alzheimer disease.