PTEN and Familial prostate cancer: TRAMP-C1/2/3 [31, 32] prostate cancer cell lines, derived from the prostatic epithelium of TRAMP mouse, and PTEN-CaP8 [33], from Pten-null transgenic mouse model of PCa, are both in strain C57BL/6; instead PNEC30, originated from neuroendocrine cell population in mouse prostate cancer, is in strain BALB/c [34].