Additionally, in the SR group, both OS and RFS were higher among subgroups of patients with solitary HCC ≤ 3 cm, multifocal HCC, solitary HCC > 3 cm, serum AFP level ≥ 400 μg/L, serum AFP level < 400 μg/L, Child-Pugh class A, Child-Pugh class B, and younger patients (aged ≤ 60 years). The gene discussed is AFP; the disease is hepatocellular carcinoma.