Since more knowledge about the pathogenesis of the disorder would result in more effective prevention and treatment strategies and investigation of correlation between schizophrenia and plasma hormones levels has received little attention in Iran, the present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals in Ahvaz, Southwest Iran. This evidence concerns the gene PRL and schizophrenia.