KLK3 and posterior cortical atrophy: On multivariate analysis including age, PSA, DRE, primary versus repeat biopsy, prostate volume and PI-RADS score, ROI size was not significant (p = 0.09) but increasing age (p = 0.001) and PI-RADS score ≥4 (p = 0.02) were predictive in detection of significant PCa.