LCN2 and kidney disorder: Because levels of urinary NGAL were significantly different according to the degree of albuminuria and increased in parallel with the severity of renal disease, reaching higher levels in patients with manifest DN, urinary NGAL levels expresses the degree of renal impairment in DN and, together with albuminuria, it could be used as a sensitive and specific markers for predicting the progression of DN [14, 17, 19, 22, 26, 31].