Urinary A1M levels were markedly elevated in diabetic patients when compared with control subjects [61, 72–74] and correlated directly with urinary albumin excretion, UACR, and serum CysC and negatively with eGFR [72–76], indicating the possible clinical application of urinary A1M as a complementary marker for early detection of DN. Here, ALB is linked to liver dysplastic nodule.