HAVCR1 and diabetes mellitus: Urinary levels of KIM-1 were significantly higher in patients with diabetes when compared with nondiabetic control subjects and correlated with urinary albumin, UACR, SCr, blood urea, and BUN, indicating the possible clinical application of urinary KIM-1 as a complementary marker for early detection of DN [14, 18, 21, 22, 27, 39].