An unequal crossover event between these genes can result in a gene variant with a CYP11B1 regulatory element and CYP11B2 catalytic sequence, i.e. regulated by ACTH but coding for aldosterone synthase activity, resulting in glucocorticoid-suppressible hyperaldosteronism (Pascoe et al., 1992; White and Pascoe, 1992). This evidence concerns the gene POMC and hyperaldosteronism.