However, thistranscript was down-regulated in MCF10A and Hs578T cells, and up-regulated in MCF7 cells.TAGLN has been shown previously to be down-regulated in breast, colon andprostate cancers and in virally transformed cells(34,35), and hence has been proposed as an early marker of transformation andtumour progression(34). The gene discussed is TAGLN; the disease is cancer.