FOXM1, FOXO1, CD24,KIAA1524 and S100A6 were predicted to have increased activity, andKDM5B, CDKN1A, EIF2AK2,TP53 and NUPR1 were predicted to have decreased activity.Some of these genes have functions that relate to BC development and progression includingFOXM(37), FOXO1(38), KIAA1524(39) and S100A6(40). The gene discussed is NUPR1; the disease is breast cancer.