Studies [56] of the metabolic disorder induced by CIH and its effect on the expression of the HIF-1/Angptl4 pathway in ApoE−/− mice after 4 weeks of CIH exposure showed that hypoxia significantly elevated Angptl4 levels in adipose tissue, inhibited lipoprotein lipase in adipose tissue, enhanced plasma TC and very low density lipoprotein-cholesterol (vLDL-C), and increased the area of AS plaques. Here, ANGPTL4 is linked to metabolic disease.