AFP and hepatocellular carcinoma: The merits gained by DHCR24 as a novel biomarker of HCV-induced HCC rely on the fact that the sensitivity of anti-DHCR24 antibodies detection was shown to be higher than that of other biomarkers (alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II) and that DHCR24 was upregulated in HCV-positive, but not HBV-positive, tissues or HBV/HCV negative HCC specimens [57].