Previous data have suggested that there is a correlation between increased sod3 mRNA production and increased growth of benign tumors [62], indicating a role for SOD3 in early tumorigenesis. In vitro studies have supported this conclusion by demonstrating that moderate overexpression of SOD3 stimulates mouse primary embryonic fibroblast (MEF) cell proliferation, mimicking the RAS oncogene response in primary cells [63] and further corroborating the close relationship of SOD3 expression and cellular growth. The gene discussed is SOD3; the disease is benign neoplasm.