Additionally, knockdown of VEGF-C in mammary cancer cell lines significantly reduces the expression of SOD3, tumor formation, and metastasis of the cells, whereas restoration of SOD3 expression in VEGF-C knockdown cells to the levels of control cells with carcinogenic characteristics partly recovers the aggressiveness of the cells, increasing both primary tumor growth and metastasis [67]. Here, SOD3 is linked to neoplasm.