Chronic liver disease with inflammation and hepatic fibrosis may cause the expression increase of vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing receptor (KDR) and Flt-1 and phosphorylated serine/threonine kinase B (pAkt) and the activation of the PI3K (phosphoinositide 3-kinase)/Akt signaling pathway promotes the production of VEGF-A in hepatocytes and expression of VEGFR-2 [9–11]. The gene discussed is KDR; the disease is Hepatic fibrosis.