Research indicated that VEGF level in chronic hepatitis, hepatic cirrhosis, and primary liver cancer was significantly higher and related to the degree of hepatic fibrosis; pathological angiogenesis mainly located in fiber interval of portal area periphery and had the tendency of invading from portal area periphery to parenchyma in accordance with fibrosis development [16, 18]. The gene discussed is VEGFA; the disease is Cirrhosis.