Patients with egg allergy had either a positive OFC or a history of at least one sign or symptom of allergy (ocular, respiratory, gastrointestinal, or cardiovascular) occurring within 1 h of egg ingestion and persistent sensitization at time of evaluation confirmed by a positive egg white skin prick test (3 mm greater than control), and either ImmunoCAP specific IgE levels ≥0.35 kU/L or Immulite specific IgE levels ≥0.1 kU/L. Here, IGHE is linked to allergic disease.