The authors confirmed a previously described role for this heat shock protein in the maintenance of RCC CSCs, as Dnajb8 KO cells showed reduced ratios of SP cells and reduced sphere-forming capacity [70, 71]. In vivo single-cell transplantation assay revealed a role for DNAJB8 in tumor initiation, while in vitro experiments did not indicate a function in stress responses [70]. This evidence concerns the gene DNAJB8 and neoplasm.