hBMSC were cultured in P2 until day 25 in BM and from day 4 until day 25 in OM/D and analyzed at nine time points for TNAP activity and gene expression of octamer binding transcription factor 4 (oct-4), core-binding factor alpha-1 (cbfa1), parathyroid receptor (pthr), bone γ-carboxylglutamic acid-containing protein (bglap), and peroxisome proliferator-activated receptor γ (pparγ). This evidence concerns the gene RUNX2 and ocular melanoma.