TGFB1 and leiomyoma: Although the causes of leiomyoma remain unknown and its pathogenesis is still little explored in the literature, the primary mechanism suggested for the extracellular matrix increase in the uterine leiomyomas development location would be the transforming growth factor beta (TGF-β) protein increase, since this protein stimulates fibroblast proliferation, thus enhancing collagen production [15, 25].